Last update
3/29/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 12 Researches
8
USERS' SCORE
Good
Based on 4 Reviews
8.4
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Vitamin B-6 [from 50 mg Coenzyme Pyridoxal-5-Phosphate (P-5-P) Monohydrate]
33 mg
1941%
Magnesium (from Magnesium Bisglycinate) (TRAACS®)
25 mg
6%
Top Medical Research Studies
9.5
We evaluated the effects of pyridoxine, or vitamin B6, on carpal tunnel syndrome through a crossover treatment involving a placebo. Our findings highlighted a significant vitamin B6 deficiency in patients, which was addressed effectively with a dosage of 100 mg, leading to symptom relief and normalization of joint flexion.
Interestingly, when patients switched to placebo, both the deficiency and symptoms returned. This cycle reinforced the idea that vitamin B6 plays a critical role in alleviating the syndrome. Overall, we found that increased B6 intake led to improved symptoms, similar to previous studies.
Interestingly, when patients switched to placebo, both the deficiency and symptoms returned. This cycle reinforced the idea that vitamin B6 plays a critical role in alleviating the syndrome. Overall, we found that increased B6 intake led to improved symptoms, similar to previous studies.
Read More
9.5
We examined the connection between vitamin B6 treatment and carpal tunnel syndrome through a detailed clinical study. A patient with severe symptoms and a notable vitamin B6 deficiency was treated with various doses of pyridoxine.
The results showed that while a low dose offered some improvement, only the higher dose effectively alleviated symptoms and corrected enzyme deficiencies. After a placebo period, symptoms worsened, highlighting the role of vitamin B6 in managing carpal tunnel syndrome.
Ultimately, this study underscores the importance of vitamin B6 and suggests that proper supplementation may help those suffering from this condition.
The results showed that while a low dose offered some improvement, only the higher dose effectively alleviated symptoms and corrected enzyme deficiencies. After a placebo period, symptoms worsened, highlighting the role of vitamin B6 in managing carpal tunnel syndrome.
Ultimately, this study underscores the importance of vitamin B6 and suggests that proper supplementation may help those suffering from this condition.
Read More
9
Vitamin B6 may alleviate CTS
We explored the effects of vitamin B6 (pyridoxine) therapy on carpal tunnel syndrome (CTS), administering doses of 100 to 200 mg daily for 12 weeks. Many patients experienced significant improvement, suggesting that this vitamin may be quite effective in alleviating symptoms.
Additionally, we found that monitoring vitamin B6 levels can aid in diagnosing deficiencies and determining the need for surgical interventions. The study also highlighted the importance of preventing CTS during pregnancy and observed symptom changes throughout the treatment.
Additionally, we found that monitoring vitamin B6 levels can aid in diagnosing deficiencies and determining the need for surgical interventions. The study also highlighted the importance of preventing CTS during pregnancy and observed symptom changes throughout the treatment.
Read More
Most Useful Reviews
9
Thumb discomfort gone
1 people found this helpful
This really helps with my trigger finger issue. It has been 11 days since I began taking it, and the trigger finger (thumb) and Carpal Tunnel Syndrome haven’t bothered me since.
Read More
9
Significant improvement
Excellent! My Carpal Tunnel Syndrome has improved significantly after taking this for a long time. 👍👍
Read More
7
Effective magnesium aid
Just what I need to combat trigger finger and Carpal Tunnel Syndrome. The magnesium is helpful too. The protocol I’m following requires 50mg three times a day with food, as prescribed by my doctor. So far, it seems effective.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 12 Researches
8
- All Researches
9.5
We investigated how vitamin B6 (pyridoxine) and riboflavin affect carpal tunnel syndrome (CTS) by analyzing specific enzyme activities in a patient with a three-year history of CTS.
After five months of riboflavin treatment, the patient showed nearly complete relief from CTS, with improved strength in hand function. When combined treatment of riboflavin and pyridoxine was applied, enzyme activities normalized and CTS disappeared completely.
Our findings suggest riboflavin's significant role in treating CTS, especially when paired with pyridoxine for enhanced outcomes.
After five months of riboflavin treatment, the patient showed nearly complete relief from CTS, with improved strength in hand function. When combined treatment of riboflavin and pyridoxine was applied, enzyme activities normalized and CTS disappeared completely.
Our findings suggest riboflavin's significant role in treating CTS, especially when paired with pyridoxine for enhanced outcomes.
Read More
9.5
We explored how vitamin B6, or pyridoxine, affects carpal tunnel syndrome alongside potential surgical treatments. Blood tests showed that patients with carpal tunnel often suffer from vitamin B6 deficiencies. Remarkably, treatment with vitamin B6 for at least 12 weeks proved effective for all patients in alleviating symptoms.
While surgery can relieve compression, it doesn't address the vitamin deficiency. Therefore, surgery should be an option only for those with significant, long-term deficiency that has caused irreversible damage to tissue.
While surgery can relieve compression, it doesn't address the vitamin deficiency. Therefore, surgery should be an option only for those with significant, long-term deficiency that has caused irreversible damage to tissue.
Read More
9.5
We evaluated the effects of pyridoxine, or vitamin B6, on carpal tunnel syndrome through a crossover treatment involving a placebo. Our findings highlighted a significant vitamin B6 deficiency in patients, which was addressed effectively with a dosage of 100 mg, leading to symptom relief and normalization of joint flexion.
Interestingly, when patients switched to placebo, both the deficiency and symptoms returned. This cycle reinforced the idea that vitamin B6 plays a critical role in alleviating the syndrome. Overall, we found that increased B6 intake led to improved symptoms, similar to previous studies.
Interestingly, when patients switched to placebo, both the deficiency and symptoms returned. This cycle reinforced the idea that vitamin B6 plays a critical role in alleviating the syndrome. Overall, we found that increased B6 intake led to improved symptoms, similar to previous studies.
Read More
9.5
We examined the connection between vitamin B6 treatment and carpal tunnel syndrome through a detailed clinical study. A patient with severe symptoms and a notable vitamin B6 deficiency was treated with various doses of pyridoxine.
The results showed that while a low dose offered some improvement, only the higher dose effectively alleviated symptoms and corrected enzyme deficiencies. After a placebo period, symptoms worsened, highlighting the role of vitamin B6 in managing carpal tunnel syndrome.
Ultimately, this study underscores the importance of vitamin B6 and suggests that proper supplementation may help those suffering from this condition.
The results showed that while a low dose offered some improvement, only the higher dose effectively alleviated symptoms and corrected enzyme deficiencies. After a placebo period, symptoms worsened, highlighting the role of vitamin B6 in managing carpal tunnel syndrome.
Ultimately, this study underscores the importance of vitamin B6 and suggests that proper supplementation may help those suffering from this condition.
Read More
9
Vitamin B6 may alleviate CTS
We explored the effects of vitamin B6 (pyridoxine) therapy on carpal tunnel syndrome (CTS), administering doses of 100 to 200 mg daily for 12 weeks. Many patients experienced significant improvement, suggesting that this vitamin may be quite effective in alleviating symptoms.
Additionally, we found that monitoring vitamin B6 levels can aid in diagnosing deficiencies and determining the need for surgical interventions. The study also highlighted the importance of preventing CTS during pregnancy and observed symptom changes throughout the treatment.
Additionally, we found that monitoring vitamin B6 levels can aid in diagnosing deficiencies and determining the need for surgical interventions. The study also highlighted the importance of preventing CTS during pregnancy and observed symptom changes throughout the treatment.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
Thumb discomfort gone
1 people found this helpful
This really helps with my trigger finger issue. It has been 11 days since I began taking it, and the trigger finger (thumb) and Carpal Tunnel Syndrome haven’t bothered me since.
Read More
9
Significant improvement
Excellent! My Carpal Tunnel Syndrome has improved significantly after taking this for a long time. 👍👍
Read More
7
Effective magnesium aid
Just what I need to combat trigger finger and Carpal Tunnel Syndrome. The magnesium is helpful too. The protocol I’m following requires 50mg three times a day with food, as prescribed by my doctor. So far, it seems effective.
Read More
7
Highly recommend product
Great! I use this for my Carpal Tunnel Syndrome and highly recommend it. It’s an excellent product.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Bernstein AL, Dinesen JS. Brief communication: effect of pharmacologic doses of vitamin B6 on carpal tunnel syndrome, electroencephalographic results, and pain. J Am Coll Nutr. 1993;12:73. PubMed
- Stransky M, Rubin A, Lava NS, Lazaro RP. Treatment of carpal tunnel syndrome with vitamin B6: a double-blind study. South Med J. 1989;82:841. PubMed
- Laso Guzmán FJ, González-Buitrago JM, de Arriba F, Mateos F, Moyano JC, et al. Carpal tunnel syndrome and vitamin B6. Klin Wochenschr. 1989;67:38. PubMed
- Ellis JM. Treatment of carpal tunnel syndrome with vitamin B6. South Med J. 1987;80:882. PubMed
- Kasdan ML, Janes C. Carpal tunnel syndrome and vitamin B6. Plast Reconstr Surg. 1987;79:456. PubMed
- Folkers K, Wolaniuk A, Vadhanavikit S. Enzymology of the response of the carpal tunnel syndrome to riboflavin and to combined riboflavin and pyridoxine. Proc Natl Acad Sci U S A. 1984;81:7076. PubMed
- Wolaniuk A, Vadhanavikit S, Folkers K. Electromyographic data differentiate patients with the carpal tunnel syndrome when double blindly treated with pyridoxine and placebo. Res Commun Chem Pathol Pharmacol. 1983;41:501. PubMed
- Ellis JM, Folkers K, Levy M, Shizukuishi S, Lewandowski J, et al. Response of vitamin B-6 deficiency and the carpal tunnel syndrome to pyridoxine. Proc Natl Acad Sci U S A. 1982;79:7494. PubMed
- Ellis J, Folkers K, Levy M, Takemura K, Shizukuishi S, et al. Therapy with vitamin B6 with and without surgery for treatment of patients having the idiopathic carpal tunnel syndrome. Res Commun Chem Pathol Pharmacol. 1981;33:331. PubMed
- Ellis J, Folkers K, Watanabe T, Kaji M, Saji S, et al. Clinical results of a cross-over treatment with pyridoxine and placebo of the carpal tunnel syndrome. Am J Clin Nutr. 1979;32:2040. PubMed
- Folkers K, Ellis J, Watanabe T, Saji S, Kaji M. Biochemical evidence for a deficiency of vitamin B6 in the carpal tunnel syndrome based on a crossover clinical study. Proc Natl Acad Sci U S A. 1978;75:3410. PubMed
- Ellis JM, Kishi T, Azuma J, Folkers K. Vitamin B6 deficiency in patients with a clinical syndrome including the carpal tunnel defect. Biochemical and clinical response to therapy with pyridoxine. Res Commun Chem Pathol Pharmacol. 1976;13:743. PubMed
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